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Testosterone Therapy: Review of Clinical Applications

Testosterone Therapy: Review of Clinical Applications

Personalized care from a board-certified urologist or male fertility expert is the healthiest way to get there. Everyone can benefit from an unbiased, listening ear now and then. I’ve referred many patients to see a therapist whose concerns resolve without testosterone therapy.

All modern day testosterone formulations are bioidentical once they get into the bloodstream. If you’ve been feeling tired, struggling to focus, or noticing a drop in mood or sex drive, it co… If you are looking for a specific code, use your browser’s Find function (Ctrl-F) to quickly locate the code in the article. Sometimes, a large group can make scrolling thru a document unwieldy. You can collapse such groups by clicking on the group header to make navigation easier.

To balance hormones and support treatment for symptoms of low testosterone in men, Anastrozole (generic Arimidex) reduces estrogen levels and the conversion of testosterone to estrogen. By boosting your body’s production of testosterone, clomiphene citrate (generic Clomid®) increases energy and improves mood and focus while preserving fertility. Testosterone is formed via the hypothalamic–pituitary–gonadal (HPG)axis. The U.S. Food and Drug Administration clarified in 2015 that prescribing testosterone for low testosterone levels due to aging constitutes off-label use. Inconsistent dosing or missed injections can lead to testosterone fluctuations, causing mood swings, fatigue, and energy crashes. Therefore, selecting a dosing schedule that aligns with one’s lifestyle is essential for treatment success.

Patients have experienced improvements in their muscle mass, lean body mass, and body fat percentage by using Sermorelin tablets in conjunction with testosterone optimization. What’s more, Sermorelin has also been shown to help promote joint health and enhance recovery from injuries. While our providers at The Edge can’t stop you or your body from aging, we can mitigate and often reverse its effects! This is where testosterone optimization through testosterone replacement therapy comes in. The process begins by meeting with a provider for your one-on-one appointment, where we’ll better understand your needs, challenges, and goals. Mean A, 5-dihydrotestosterone (DHT) and B, estradiol (E2) concentrations on weekly subcutaneous (SC) injections of 75 mg testosterone enanthate.

Peptide therapy through The Edge is another effective way to increase your body’s natural production of growth hormones. Based on your body’s own unique profile and needs, we lab-develop our synthetic peptides and ship the prescription right to your home. From there, patients should administer their peptides through a subcutaneous injection just before bed, 5 days per week. We prioritize weekly testosterone injection because it gives us more control over your treatment.

Brain fog should start to clear up, and your motivation and drive should improve. The answer here varies, depending on your doctor’s preference but also your dosage. Some guys don’t want to self-inject twice per week, so they want to get the whole week’s dose delivered at once. However, there’s no difference in the time of day you’re injecting; I’ve not seen a study that indicates there’s any change in efficacy between the morning and the afternoon or the evening.

People can also use testosterone injections to treat delayed puberty or certain signs of menopause. A 2019 review and meta-analysis of previous studies found that testosterone therapy improved sexual desire, pleasure, and satisfaction in comparison with a placebo or other forms of hormone therapy. However, a significant number of these patients did not have low enough testosterone levels to receive a diagnosis of hypogonadism. Hypogonadism is when the testes are not producing enough testosterone or sperm. They provide a dose of testosterone, which is one of the sex hormones, to the bloodstream.

If a man’s testosterone is below the normal range, it’s best to repeat it once more to be sure before starting testosterone therapy — often staying on it indefinitely. Men get started on testosterone replacement and they feel better, but then it’s hard to come off of it. Men can often feel a big difference when they stop therapy because their body’s testosterone production has not yet recovered. Research shows that bone density increases with testosterone treatment as long as the dose is high enough. Clinical trials on the effect of testosterone on bone density found increases in spinal and hip bone density.

Lastly, SubQ injection sites are more susceptible to infection of the injected area than via IM, as the area is less vascularized. On the flip side, with SubQ injections, irritating solutions or more concentrated dosages might cause sloughing off of the skin epithelial tissue. There is less blood flow to quickly absorb the injection of testosterone. The absorption of your testosterone is slower as there are fewer blood vessels in the fatty tissue; this is actually an advantage, however, if you’re looking for a prolonged effect. SubQ shots are less painful since you’re using smaller gauge needles and injecting into fatty tissue beneath the skin versus into your muscle.

Insertion of more than 6 pellets every 3 months will not be considered reasonable and necessary. Medicare may only cover the number of pellets actually implanted in the patient (maximum of 6 pellets); wastage is not covered. Meanwhile, patients injected with testosterone undecanoate reached a peak of 813 ng/dL by day seven, which declined to between 323 to 339 ng/dL 10 weeks after each injection. This was based on the recommended dosing schedule of 750-mg injections at weeks 0 and four and then every 10 weeks thereafter for a total of nine injections. When compared to testosterone cypionate and testosterone ethanate, troughs were seen later and resulted in fewer side effects.